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Spectrum of clinical presentation, treatment and prognosis in a series of eight patients with leukaemia cutis
Author(s) -
Watson K. M. T.,
Mufti G.,
Salisbury J. R.,
Vivier A. W. P.,
Creamer D.
Publication year - 2006
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2005.02022.x
Subject(s) - medicine , dermatology , refractory (planetary science) , presentation (obstetrics) , cutis , broad spectrum , retrospective cohort study , surgery , chemistry , combinatorial chemistry , physics , astrobiology
Summary All types of leukaemia can disseminate to the skin, producing cutaneous deposits known as leukaemia cutis (LC). We undertook a retrospective study to review the clinical presentations, treatment and outcome of eight patients with LC managed in our department over a period of 12 years. The clinical phenotype varied, with erythematous papules and nodules occurring with greatest frequency. Infiltrated haemorrhagic plaques and perifollicular acneiform papules were also seen. Although patients were treated aggressively for their underlying leukaemia, and received therapy directed towards LC, they tended to be refractory to treatment and the diagnosis was generally associated with a poor prognosis. The exception was a patient with chronic lymphocytic leukaemia, who survived 3 years after developing LC.