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Cutaneous manifestations of granulocyte colony‐stimulating factor
Author(s) -
White J. M. L.,
Mufti G. J.,
Salisbury J. R.,
Du Vivier A. W. P.
Publication year - 2006
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2005.01996.x
Subject(s) - granulocyte colony stimulating factor , medicine , granulocyte , immunology , dermatology , chemotherapy
Summary Granulocyte colony‐stimulating factor (GCSF) is a recombinant human growth factor widely used in haematology. It is known to cause cutaneous vasculitis and neutrophilic dermatoses. We present three cases of Sweet's syndrome (SS) associated with GCSF use. Raised GCSF levels have been demonstrated in patients with SS. GCSF is the best understood mechanism by which neutrophil accumulation occurs and shows a dose‐dependent effect in provoking SS.