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Epidermolysis bullosa acquisita: diagnosis by fluorescence overlay antigen mapping and clinical response to high‐dose intravenous immunoglobulin
Author(s) -
Campos M.,
Silvente C.,
Lecona Manuel,
Suárez R.,
Lázaro P.
Publication year - 2006
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2005.01989.x
Subject(s) - epidermolysis bullosa acquisita , medicine , autoantibody , antibody , lamina densa , dermatology , basement membrane , bullous pemphigoid , pathology , immunology
Summary Epidermolysis bullosa acquisita (EBA) is a chronic, subepidermal blistering disease characterized by the presence of autoantibodies to type VII collagen, located below the lamina densa of the basement membrane zone (BMZ). There is a large clinical and histological overlap between EBA and other subepidermal autoimmune bullous diseases, therefore, complex immunological techniques are required to make an accurate diagnosis. Therapy of EBA is also a difficult issue. Most patients do not respond to several common immunosuppressive agents. We describe a patient who has shown a good response to high‐dose intravenous immunoglobulin therapy.