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Vitiligo with inflammatory raised borders, associated with atopic dermatitis
Author(s) -
Sugita K.,
Izu K.,
Tokura Y.
Publication year - 2006
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2005.01987.x
Subject(s) - vitiligo , atopic dermatitis , medicine , immunology , dermatology , cd8 , cxcr3 , antecedent (behavioral psychology) , inflammation , antigen , chemokine , chemokine receptor , psychology , developmental psychology
Summary A 31‐year‐old man had had atopic dermatitis since childhood and developed vitiligo with inflammatory raised borders 5 years prior to presentation. Immunohistochemically, CD4+ T cells infiltrated predominantly in the raised border of vitiligo, while CD8+ T cells were present just outside of the borders, suggesting that CD8+ cells were an antecedent to the CD4+ cells. Despite the presence of atopic dermatitis, the percentage of CXCR3+ CD4+ Th1 cells increased in the patient's peripheral blood, compared with a representative atopic patient showing a high percentage of CCR4+CD4+ Th2 cells. This case suggests that vitiligo with inflammatory raised borders can occur even in patients with atopic dermatitis when Th1 cells are activated and overcome the Th2‐dominant state.