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Early but not lasting improvement of recalcitrant subcorneal pustular dermatosis (Sneddon–Wilkinson disease) after infliximab therapy: relationships with variations in cytokine levels in suction blister fluids
Author(s) -
Bonifati C.,
Trento E.,
Cordiali Fei P.,
Muscardin L.,
Amantea A.,
Carducci M.
Publication year - 2005
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2005.01902.x
Subject(s) - medicine , dapsone , infliximab , dermatology , intertriginous , etretinate , acitretin , suction , suction blister , disease , surgery , psoriasis , pathology , mechanical engineering , engineering
Summary Subcorneal pustular dermatosis (SCPD) is an uncommon disorder, characterized by a chronic relapsing vesiculopustular eruption, mainly involving the trunk and intertriginous areas, and usually seen in women > 40 years old. Various therapies have been reported to be effective in treating SCPD, such as dapsone, systemic glucocorticoids, acitretin, etretinate, infliximab and phototherapy. We report a case of a 54‐year‐old woman affected by SCPD who after failure of different therapies showed a dramatic but only temporary improvement of her disease during a cycle of therapy with infliximab. In addition, an array of cytokines was simultaneously measured in suction blister fluids obtained from involved or uninvolved skin at various time intervals during the first 12 weeks of observation.