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Coexistence of psoriasis and linear IgA disease in a patient with recent herpes zoster infection
Author(s) -
Cooke N.,
Jenkinson H.,
Wojnarowska F.,
McKenna K.,
Alderdice J.
Publication year - 2005
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2005.01872.x
Subject(s) - psoriasis , medicine , autoantibody , immunology , disease , antibody , antigen , epitope , autoimmune disease , autoimmunity , dermatology , virology , pathology
Summary We report the case of a 29‐year‐old man with chronic plaque psoriasis who developed linear IgA disease following herpes zoster infection. There has only been one previous report describing the coexistence of psoriasis and linear IgA disease, which was confirmed by immunopathological studies. In our patient, immunoblotting studies identified IgA antibodies binding to BP180 and BP230 antigens, and IgG autoantibodies binding weakly to the BP180 antigen. This is an interesting case that we believe is an example of epitope spreading in the development of autoimmune subepidermal bullous diseases.