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A case of multicentric reticulohistiocytosis with multiple lytic skull lesions
Author(s) -
Ho S. G. Y.,
Yu R. C.
Publication year - 2005
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2005.01843.x
Subject(s) - medicine , lytic cycle , skull , pathology , malignancy , etiology , proinflammatory cytokine , inflammation , immunology , anatomy , virus
Summary Multicentric reticulohistiocytosis (MR) is a rare multisystemic disorder of unknown aetiology characterized by cutaneous and joint manifestations. It is associated with malignancy in up to 31% of cases. Common radiological findings are peri‐articular erosions and osteolytic punched‐out areas. We present a case of MR with cutaneous nodules, joint pains, and multiple lytic skull lesions − a combination that has not been described before. Osteolytic activity of proinflammatory cytokines (tumour necrosis factor‐α and interleukin‐1) may explain the peri‐articular erosions often seen in MR, and the multiple lytic skull lesions seen in our patient.