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Acinic cell carcinoma on the lower lip resembling a mucocele
Author(s) -
Cho J. H.,
Yoon S. Y.,
Bae E. Y.,
Lee C. N.,
Lee J. D.,
Cho S. H.
Publication year - 2005
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2005.01814.x
Subject(s) - mucocele , acinic cell carcinoma , medicine , carcinoma , pathology , dermatology , mucoepidermoid carcinoma
Summary A 64‐year‐old woman presented with a 2‐week history of an asymptomatic mass involving the lower lip. Histopathological examination showed a well‐circumscribed tumour composed of many lobules separated by thin, fibrous connective tissue. Individual lobules were composed of round or polyhedral tumour cells, which had a characteristic finely granular and vacuolated cytoplasm and eccentric hyperchromatic nuclei. Positive staining was observed with Periodic acid–Shiff, and immunohistochemistry for cytokeratin, α‐1 antitrypsin, and S‐100 protein resulting in a final diagnosis of acinic cell carcinoma. Acinic cell carcinoma represents a well‐established, although uncommon, entity in the classification of neoplasms of salivary gland origin. The parotid salivary gland is the most frequent site of acinic cell carcinoma, whereas the lip is a particularly unusual site. The unusual presentation of this tumour may lead to confusion with a mucocele. Given these findings, we suggest that acinic cell carcinoma should be considered in the differential diagnosis of any mucocele‐like mass on the lower lip.