Premium
Vancomycin‐induced linear IgA bullous disease presenting as toxic epidermal necrolysis
Author(s) -
Waldman M. A.,
Black D. R.,
Callen J. P.
Publication year - 2004
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2004.01649.x
Subject(s) - toxic epidermal necrolysis , dapsone , medicine , vancomycin , erythema multiforme , dermatology , dermatitis herpetiformis , bullous pemphigoid , cicatricial pemphigoid , erythroderma , discontinuation , antibiotics , pemphigoid , immunology , pathology , staphylococcus aureus , disease , surgery , antibody , microbiology and biotechnology , biology , bacteria , genetics
Summary Linear IgA bullous dermatosis (LABD) is a rare autoimmune vesiculobullous disorder characterized by variable clinical presentations that may mimic bullous pemphigoid, dermatitis herpetiformis, cicatricial pemphigoid and erythema multiforme. A few cases of drug‐induced LABD that clinically resembled toxic epidermal necrolysis (TEN) have been reported. A subset of patients with LABD have been found to be drug‐induced; the most common drug being vancomycin. The diagnosis of LABD is confirmed by the presence of a linear band of IgA along the basement membrane zone on direct immunofluorescence microscopy. We report a case of a 77‐year‐old man who presented to us with vancomycin‐induced LABD that presented clinically as TEN. He had a complete recovery over a 3‐week period following discontinuation of the vancomycin and the addition of oral dapsone therapy. It is important to be aware that drug‐induced LABD can mimic TEN.