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Evidence for polyclonal infection of Epstein–Barr virus in a patient with primary cutaneous anaplastic large cell lymphoma
Author(s) -
Shimauchi T.,
Onoue A.,
Yamamoto O.,
Hino R.,
Tokura Y.
Publication year - 2004
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2004.01538.x
Subject(s) - lymphoma , epstein–barr virus , polyclonal antibodies , cd30 , virus , anaplastic large cell lymphoma , monoclonal , virology , southern blot , gammaherpesvirinae , biology , large cell lymphoma , pathogenesis , epstein–barr virus infection , in situ hybridization , pathology , herpesviridae , monoclonal antibody , medicine , viral disease , immunology , antibody , messenger rna , gene , genetics
Summary We report a case of CD30 + primary cutaneous anaplastic large cell lymphoma. The lymphoma cells were shown to express the Epstein–Barr virus (EBV)‐encoded small RNAs by in situ hybridization and to have EBV genomes by PCR, whereas no monoclonal band was detected by Southern blot analysis using the EBV terminal repeat probe. These data suggested polyclonal infection by EBV, which provides evidence that EBV plays little part in the pathogenesis of this tumour even in the infected cases.