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Discoid lupus erythematosus‐like eruption induced by infliximab
Author(s) -
Stratigos A. J.,
Antoniou C.,
Stamathioudaki S.,
Avgerinou G.,
Tsega A.,
Katsambas A. D.
Publication year - 2004
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2004.01471.x
Subject(s) - medicine , infliximab , discoid lupus erythematosus , rheumatoid arthritis , lupus erythematosus , dermatology , context (archaeology) , rash , rheumatoid factor , systemic lupus erythematosus , discontinuation , pathology , immunology , antibody , tumor necrosis factor alpha , disease , paleontology , biology
Summary Lupus erythematosus‐like syndromes have been reported as an adverse effect of anti‐tumour necrosis factor‐α therapy. We report the case of a patient with rheumatoid arthritis who developed a discoid lupus erythematosus‐like eruption after treatment with infliximab. The rash consisted of diffuse scaly erythematous plaques on the face, trunk and extremities, and occurred in the context of elevated anti‐nuclear and anti‐double‐stranded DNA antibody titres. Direct immunofluorescence of lesional skin showed linear deposition of IgG, IgM and C 3 . The lesions resolved completely after the discontinuation of infliximab and with the use of anti‐malarial therapy. We discuss the clinical, histological and immunohistochemical features of this case and review the literature with respect to the incidence of lupus erythematosus‐like syndromes in patients receiving tumour necrosis factor‐α antagonists.