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Warfarin skin necrosis associated with protein S deficiency and a mutation in the methylenetetrahydrofolate reductase gene
Author(s) -
Byrne J. S.,
Abdul Razak A. R.,
Patchett S.,
Murphy G. M.
Publication year - 2004
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2004.01443.x
Subject(s) - warfarin , methylenetetrahydrofolate reductase , medicine , protein s deficiency , venous thrombosis , necrosis , mutation , thrombosis , gastroenterology , gene , biology , genetics , allele , atrial fibrillation
Summary The use of warfarin is rarely complicated by skin necrosis. We describe a 50‐year‐old woman who presented with a left leg deep venous thrombosis and subsequent pulmonary embolism. She was initially anticoagulated with low‐molecular weight heparin and subsequently warfarin. Within 4 days abdominal skin necrosis developed. Investigations revealed the presence of protein S deficiency and in addition, a mutation in the methylenetetrahydrofolate reductase gene ( MTHFR ). We present, to our best knowledge, the first case of warfarin skin necrosis associated with a methylenetetrahydrofolate reductase mutation.