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Epidermolysis bullosa acquisita in childhood – a case mimicking chronic bullous dermatosis of childhood
Author(s) -
RK S.B.P.,
O K.H.C.,
YOUN J.I.,
HWANG D.H.,
KIM S.C.,
CHUNG J.H.
Publication year - 1997
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1997.tb01072.x
Subject(s) - epidermolysis bullosa acquisita , medicine , dermatology , epidermolysis bullosa , bullous pemphigoid , immunology , antibody
Summary Epidermolysis bullosa acquisila (EBA) is rarely reported in childhood, hut we mm describe a 6‐year‐old Korean girl with the condition. She presented with multiple tense bullae annularly distributed on the perioral, periorbital and genital areas, and was successfully treated with dapsoae. The clinical and histological features were similar to those of chronic bullous dermatosis of childhood. We review seven previously reported childhood EBA cases and contrast their features with those of adult EBA. We suggest that some childhood EBA is different from the adult form and shares features with chronic bullous dermatosis of childhood. Epidermolysis bullosa acquisita (EBA) is an acquired, chronic, subepidermal bullous disease, 1 characterised by IgG autoantibodies reacting with type VII collagen of the fibrils beneath the basement membrane Zone of the stratified squamous epithelium. 2,3 Its clinical and epidemiological features are not fully understood, and only a few cases in children have so far been reported. 4–8