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Malignant blue naevus with distant subcutaneous metastasis
Author(s) -
BÖNI R.,
PANIZZON R.,
BÖNI R.A.MUCH,
STEINERT H.,
DUMMER R.
Publication year - 1996
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1996.tb00147.x
Subject(s) - medicine , metastasis , dermatology , cancer
Summary Malignant blue naevus is a distinct but rarely documented variant of malignant melanoma, and we describe the triple recurrence of a suprapatellar cellular blue naevus over 12 years in a middle‐aged woman. Staging investigations revealed a distant subcutaneous metastasis of the right thigh. Immunohistochemistry of the primary lesion and all recurrences showed S‐100, HMB‐45, NK1/C‐3 and Ki‐67 positive cells. However, non‐malignant cellular blue naevi from five consecutive other patients were all Ki‐67 negative. The change from negative to positive Ki‐67 responsivity may therefore be a valuable marker of malignant and metastatic potential in early cellular blue naevi.