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The sweat of patients with atopic dermatitis contains specific IgE antibodies to inhalant allergens
Author(s) -
JUNG K.,
SCHLENVOIGT G.,
LADWIG K.,
HERRMANN D.,
MOTHS C.,
LINSE R.,
NEUMANN Ch.
Publication year - 1996
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1996.tb00120.x
Subject(s) - immunoglobulin e , atopic dermatitis , immunoassay , immunology , nephelometry , atopy , medicine , allergen , sweat , radioallergosorbent test , antibody , allergy , seborrhoeic dermatitis , dermatology
Summary We have investigated levels of total and specific against inhalant allergens in the sweat of 15 patients with atopic dermatitis, 10 patients with allergic rhinitis and high levels of specific IgE in the serum, and five patients with psoriasis without atopy as controls, by means of various commercial methods such as fluorescence immunoassay, nephetometry, chemiluminescence assay, enzyme immunoassay and the radioallergosorbent lest. Total IgE and specific IgE antibodies were detectable in the sweat of patients with atopic dermatitis as well as of patients with allergic rhinitis alone. These levels of total IgE in the sweat correlated with the severity of the skin disease ( P < 0·05). By means of the Ciba Corning assay ( P < 0·001), the fluorescence immunoassay ( P < 0·05) and the nephelometry assay ( P < 0·05), positive correlations were then established between the levels of total IgE in the serum and the sweat. Moreover, specific IgE antibodies to birch pollen and Dermatophagoides pteronyssinus were detectable in the sweat and correlated positively with these specific IgE levels in the serum ( P < 0·05). Further, the specific IgE levels against these allergens in the sweat also correlated with the severity of dermatitis ( P < 0·05). It is suggested that these specific IgE antibodies against certain inhalant allergens in the sweat of patients with atopic dermatitis may play a role in allergen trapping in the skin.