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The kinetics of skin thinning induced by topical fluticasone propionate 0·05% cream in volunteer subjects
Author(s) -
DYKES P.J.,
MARKS R.,
HILL S.,
MILLS C.,
EASTWOOD R.
Publication year - 1996
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1996.tb00058.x
Subject(s) - fluticasone propionate , volunteer , medicine , corticosteroid , placebo , dermatology , atrophy , double blind , fluticasone , pathology , alternative medicine , agronomy , biology
Summary Fluticasone propionate (FP) 0·05% (Cutivate TM ) cream is a novel corticosteroid used for the treatment of corticosteroid‐responsive dermatoses. To date there are no published data concerning its effect on cutaneous atrophy. This randomized, double‐blind study of 40 volunteer subjects was performed to investigate the kinetics of skin thinning induced by topical 0·05% FP cream vs. placebo after once‐daily application for 2–8 weeks. The results of this study showed no significant effect on the skin thickness of subjects after 8 weeks' treatment with 0·05% FP cream compared with placebo.