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Effects of H 1‐ and H 2‐ antihistamines on platelet‐activating factor and bradykinin‐induced inflammatory responses in human skin
Author(s) -
SANSOM J.E.,
BROOKS J.,
BURTON T.L.,
ARCHER C.B.
Publication year - 1996
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1996.tb00008.x
Subject(s) - platelet activating factor , terfenadine , bradykinin , antagonist , doxepin , medicine , pharmacology , histamine , receptor
Summary Previous studies show that oral antihistamines affect the Weal and flare response to intradermal injections of the inflammatory mediators platelet‐activating factor (PAF) and bradykinin (BK). The aim of this study was to compare the effects of terfenadine (an H 2 ‐antagonist) and cimetidine (an H 2 ‐antagonist) on weal and Hare responses to PAF and BK in healthy non‐atopic human volunteers. The effects of doxepin on PAF responses were investigated, as there is evidence that doxepin may have direct anti‐PAF ejects in addition to its known antihisiaminic actions.