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Endothelial cell activation in cutaneous vasculitis
Author(s) -
JURD K.M.,
STEPHENS C.J.M.,
BLACK M.M.,
HUNT B.J.
Publication year - 1996
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1996.tb00007.x
Subject(s) - thrombomodulin , medicine , vasculitis , immunology , von willebrand factor , endothelium , pathology , endothelial stem cell , plasminogen activator , biology , thrombin , platelet , biochemistry , disease , in vitro
Summary Markers of endothelial cell activation were measured in 28 patients presenting with various forms of limited or focal type cutaneous vasculitis. Plasma levels of tissue plasminogen activator antigen (t‐PA:Ag), plasminogen activator inhibitor type 1 antigen(PAI‐I; Ag) and PAI‐1 activity, fibrin plate, von Willebrand factor antigen (vWF:Ag), tissue factor (TF) and soluble thrombo‐modulin (sTM) were measured. In comparison with the control group [n = 20) there was a significant increase in t‐PA: Ag vWF:Ag and TF ( P < 0.05, Mann Whitney U ‐test) in the cutaneous vasculitis group This study confirms that measurable degrees ol erido‐thelial activation occur in cutaneous vasculitis.