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Clinical manifestations in 100 Japanese bullous pemphigoid cases in relation to autoantigen profiles
Author(s) -
TANAKA M.,
HASHIMOTO T.,
DYKES P.J.,
NISHIKAWA T.
Publication year - 1996
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1996.tb00006.x
Subject(s) - bullous pemphigoid , medicine , pemphigoid , dermatology , immunology , antibody
Summary The relationship between clinical findings and antigen profiles in 100 bullous pemphigoid (BP) patients has been investigated. The patients were divided into four groups based upon the results of immunoblot analysis, namely patients whose sera detected the 230‐kPa BP antigen (BP230) and the 180‐kDa BP antigen (BP180), those recognizing either BP23Q or BP180 alone, and those recognizing neither antigen, analysis by the chi‐squared test showed predominant occurrence of oral ( P < 11(15) and facial lesions ( P < 0.005) in patients whose sera detected BP180, and these patients also tended to have more extensive lesions ( P < 0.005). Patients that were positive for UP 180 alone needed treatment with higher doses of steroids than the patients positive for BP230 alone ( P < 0.05). Furthermore, all rue recalcitrant cases, which did not respond well to steroid treatment, were shown to possess auto antibodies against UP I NO in their sera. Patients with antibodies to BP230 had a tendency to have a high titre of anti‐HMZ antibodies ( P < 0 (105). These results suggest that anti‐BPI80 antibodies nun be more related to the disease severity than anti‐BP230 antibodies.