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Massive isotretinoin intoxication
Author(s) -
AUBIN S.,
LORKTTE G.,
MULLER C.,
VAILLANT L.
Publication year - 1995
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1995.tb01341.x
Subject(s) - isotretinoin , medicine , dermatology , medical emergency , intensive care medicine , acne
Summary We report a case of acute intoxication due to a massive overdose of isotrerinoin. A 29‐year‐old male patient ingested 900 mg of isotretinoin corresponding to 12·5mg (kg/day) or 30 times the prescribed dosage and 1 day later the patient experienced mild headache. Forty‐eight hours later, cheilitis, diffuse cutaneous xerosis and desquamation of the forehead and of the external auditory meatus occurred; cutaneous xerosis and cheilitis resolved spontaneously. We determined the serum level of isotretinoin and of 4‐oxo‐isotretinoin, its natural metabolite in sera taken 4, 5, 6 and 11 days following ingestion. The side‐effects were mild and represented only exacerbations of some common isotretinoin side‐effects. To date, three other cases of isotretinoin overdosage have been reported. There was a low toxicity of isotreitnoin overdose.