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HLA antigens in Omani patients with vitiligo
Author(s) -
VENKATARAM M.N.,
WHITE A.G.,
LEENY W.A.,
SUWAID A.R.AL.,
DAAR A.S.
Publication year - 1995
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1995.tb01279.x
Subject(s) - vitiligo , family history , medicine , incidence (geometry) , human leukocyte antigen , population , antigen , immunology , disease , gastroenterology , dermatology , physics , environmental health , optics
Summary Fifty native Omanis with vitiligo were studied to compare the incidence of HLA ABC and DR antigens with a control population. HLA Bw6 was found in 82% of patients compared with 49% controls ( P c = 0.0009 RR = 4.56) and HLA DR7 occurred in 40% of patients and 9% in controls ( P c = 0.00075 RR = 6.17). HLA DR7 was significantly increased in those patients with acrofacial, compared to focal disease (57% vs. 24% P = 0.038). Sixty‐six per cent of the patients in this study had parents who were consanguineous and a positive family history was only found in this group with an incidence of 32%. HLA Bw4 segregated 100% with patients with a positive family history compared with 48% in consanguineous patients without a positive family history ( P c = 0.011 RR = 23). Vitiligo appears to be associated with different HLA antigens in different ethnic groups.