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Decreased expression of collagen and fibronectin genes in striae distensae tissue
Author(s) -
LEE K.S.,
RHO Y.J.,
JANG S.I.,
SUH M.H.,
SONG J.Y.
Publication year - 1994
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1994.tb01196.x
Subject(s) - elastin , fibronectin , connective tissue , hydroxyproline , procollagen peptidase , fibroblast , medicine , messenger rna , pathology , gene , endocrinology , biology , extracellular matrix , genetics , cell culture
Summary Striae distensae are characterized by a thinning of connective tissue stroma to produce linear, atrophic‐appearing skin. Excessive adrenocortical activity, genetic factors and inherited defects of connective tissues, etc. are important causative factors in the formation of striae distensae, but the basic aetiology is not known. Total RNA was extracted from skin biopsies of five patients with striae distensae. The expression of genes coding for types I and III procollagen, elastin, fibronectin and β‐actin were studied and compared with those of four sex‐ and age‐matched healthy individuals. The percentages of types I and III procollagen mRNA were 9.9 ± 2.9% (mean ± s.d.) and 10.6 ± 1.6%, respectively, of the corresponding controls. The value for fibronectin mRNA in striae distensae was 7.3 ± 1.8% of the control. The steady‐state ratio fibronectin/type I procollagen mRNAs was 0.12 ± 0.01 in striae distensae and (MS ± 0.01 in the control. These observations suggest that expression of collagens, elastin and fibronectin genes are apparently decreased, and that there is a marked alteration of fibroblast metabolism, in striae distensae.