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Follicular toxic pustuloderma associated with allopurinol
Author(s) -
FITZGERALD D.A.,
HEAGERTY A.H.M.,
STEPHENS M.,
SMITH A.G.
Publication year - 1994
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1994.tb01177.x
Subject(s) - allopurinol , toxic epidermal necrolysis , medicine , dermatology , erythroderma , rash , exfoliative dermatitis , gout , erythema , pathology
Summary Allopurinol is widely prescribed for primary and secondary hyperuricaemia, and cutaneous adverse reactions are seen in 0.8‐2.1% of recipients. 1,2 The majority of these are mild and include pruritus, diffuse or maculo‐papular erythema, urticaria and ichthyosis. 3 More severe reactions are well recognized and include exfoliative dermatitis, toxic epidermal necrolysis and a generalized hyper‐sensitivity syndrome. 3–5 The latter typically comprises fever, rash, hepatic and renal dysfunction and eosinophil leucocytosis. 5 The occurrence of toxic pustuloderma due to allopurinol, confirmed by re‐challenge, is reported.