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Evaluation of 0.75% metronidazole gel in acne—a double‐blind study
Author(s) -
TONG D.,
PETERS W.,
BARNETSON R.St.C.
Publication year - 1994
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1994.tb01170.x
Subject(s) - acne , metronidazole , dermatology , double blind study , medicine , double blind , microbiology and biotechnology , antibiotics , pathology , biology , alternative medicine , placebo
Summary Metronidazole, an imldazole, is an antibiotic with established efficacy against anaerobic bacteria. To date, however, there are no published data concerning the efficacy of topical metronidazole in the treatment of acne. This randomized, double‐blind prospective clinical study of 96 patients was performed to investigate the efficacy and tolerability of 0.75% metronidazole gel vs. placebo in the treatment of mild to moderate acne. The results of this study showed no significant benefit in using 0.75% metronidazole gel over placebo in reducing counts of inflamed and non‐inflamed lesions of acne. There was also no statistically significant difference between the two groups at any stage in the trial when skin tolerability was assessed.