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Clinical and histological features of‘mechanic's hands' in a patient with antibodies to Jo‐1—a case report
Author(s) -
MITRA D.,
LOVELL C.L.,
MACLEOD T.I.F.,
TAN R.S.H.,
MADDISON P.J.
Publication year - 1994
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1994.tb01144.x
Subject(s) - medicine , antibody , dermatology , pathology , immunology
Summary The clinical and histological features of‘mechanic's hands' are described in a patient with polymyositis characterized serologically b6y antibodies to histidyl t RNA synthetase (Jo‐1). Although distinctive cutaneous lesions have only recently been associated with the ‘anti‐synthetase syndrome’. It is becoming apparent that recognition of subsets within the spectrum of polymyositis/dermatomyositis characterized by certain clinical and serological features not only have prognostic significance, but also may provide insights into mechanisms of disease.