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Sweet's syndrome associated with trans‐retinoic acid treatment in acute promyelocytic leukemia
Author(s) -
COX N.H.,
O'BRIEN H.A.W.
Publication year - 1994
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1994.tb01115.x
Subject(s) - neutrophilia , acute promyelocytic leukemia , sweet's syndrome , medicine , malaise , white blood cell , sweet syndrome , leukocytosis , tretinoin , immunology , retinoic acid , dermatology , biology , biochemistry , gene
Summary A case of acute promyelocytic leukemia is reported in which Sweet's syndrome developed at the time of an improvement in white blood cell count due to transretinoic acid. Acute febrile neutrophilic dermatosis (Sweet's syndrome) is a disorder characterized by acute onset of inflammatory skin nodules associated with systemic features which include malaise, fever and neutrophilia. Many triggers and associated disorders have been identified since the syndrome was described, the most important being the association with haematological diseases including leukemia' and other myeloproliferative disorders. 2 We describe a case apparently provoked by drug therapy.