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Generalized melanosis with malignant melanoma metastasizing to skin—a pathological study with S‐100 protein and HMB‐45
Author(s) -
PÉČ J.,
PLANK L.,
MINÁRIKOVÁ E.,
PALENČÁROVÁ E.,
ROLLOVÁ Y.,
LAZÁROVÁ Z.,
AUXTOVÁ S.,
LAUKO L.
Publication year - 1993
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1993.tb02250.x
Subject(s) - melanosis , melanoma , medicine , dermatology , pathological , hmb 45 , melanin , pathology , cancer research , biology , genetics
Summary A patient with primary malignant melanoma localized to the right gluteal region is described. Four years later and alter intercurrent influenza, disseminated metastases of malignant melanoma to the skin occurred. After a further 6 months melanodermia developed and lasted until the death of the patient (6 months later). Autopsy revealed melanosis of the visceral organs. Histology taken from internal organs using S‐100 protein and HMB‐45 melanoma methods confirmed metastases of malignant melanoma to the skin, oral cavity, palatal tonsils, nasal and nasopharyngeal mucosae, lungs, myocardium and brain. The authors discuss the mechanism of melanosis—a rare sign in patients with metastasizing malignant melanoma.