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Effect of a topical erythromycin—zinc formulation on sebum delivery. Evaluation by combined photometric—multi‐step samplings with Sebutape®
Author(s) -
PIÉRARD G.E.,
PIÉRARDFRANCHIMONT C.
Publication year - 1993
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1993.tb02238.x
Subject(s) - erythromycin , medicine , zinc , dermatology , chemistry , antibiotics , organic chemistry , biochemistry
Summary Zinc displays‘in vitro’some antiandrogen activity through an inhibition of the 5α‐reductase activity. The clinical relevance of this effect is unknown, particularly during zinc therapy of acne. As sebum production could he a pharmacological target, a sensitive method was used for measuring the rate of sebum delivery to the skin surface during treatment with a topical 4% crythromy‐cin‐1·2% zinc acetate formulation. A series of four successive 1‐h samplings with Sebutape® was taken to derive the rate of sebum output from the slope of the regression line given by cumulative data. As a control the classical photometric method was used. Such combined evaluation revealed a sebosuppressive effect for the topical zinc formulation tested.