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Protein S deficiency in a patient with necrotizing cellulitis
Author(s) -
JOLY P.,
CHOSIDOW O.,
GOUAULTHEILMANN M.,
LEVENT M.,
ROUJEAU J. C.,
REVUZ J.
Publication year - 1993
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1993.tb02203.x
Subject(s) - cellulitis , subclinical infection , pathogenesis , medicine , penis , immunology , pathology , dermatology , surgery
Summary A case of necrotizing cellulitis of the penis is reported. In this patient, transient functional protein S deficiency during the infectious process was demonstrated with a marked decrease of free protein S and elevated C4b‐binding protein levels. Moreover, by investigating other members of this patient's family it was possible to demonstrate a subclinical inherited protein S deficiency. In this study it is suggested that the profound and transient decrease of functional protein S observed in this patient during infectious cellulitis, may have contributed to the pathogenesis of tissue necrosis.