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Secondary localized cutaneous amyloid in Bowen's disease
Author(s) -
SPEIGHT E. L.,
MILNE D. S.,
LAWRENCE C. M.
Publication year - 1993
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1993.tb02191.x
Subject(s) - newcastle upon tyne , medicine , dermatology , history , family medicine , library science , art history , computer science
Summary A case of Bowen's disease is described in which striking quantities of amyloid were detected in the papillary dermis visualized easily by routine haematoxylin and eosin staining. The material showed positive labelling with an antikeratin monoclonal antibody consistent with the proposed origin of the amyloid as degenerate keratinocytes. The pathobiology of amyloid associated with dysplastic squamous lesions is discussed.