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Centroblastic transformation of chronic lymphocytic leukaemia with primary skin involvement—cutaneous presentation of Richter's syndrome
Author(s) -
ZARCO C.,
LAHUERTAPALACIOS J. J.,
BORREGO L.,
TOSCANO R.,
GIL R.,
IGLESIAS L.
Publication year - 1993
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1993.tb02184.x
Subject(s) - medicine , presentation (obstetrics) , chronic lymphocytic leukemia , transformation (genetics) , dermatology , pathology , immunology , leukemia , surgery , biology , biochemistry , gene
Summary The development of a large‐cell non‐Hodgkin's lymphoma in a patient suffering from chronic lymphocytic leukaemia is known as Richter's syndrome, representing one of the possible anaplastic transformations of the leukaemia. Cutaneous involvement is an extremely rare event. The case of a 45‐year‐old man with B‐cell chronic lymphocytic leukaemia is reported. Five years later multiple cutaneous nodules developed on his extremities. Biopsies of the skin showed a diffuse large‐cell lymphoma, bearing the same cell surface immunoglobulin light chain isotype as the leukaemia, suggesting the original relationship between both neoplasms.