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Effect of platelet‐poor plasma from patients with neurofibromatosis on the growth of cultured neurofibroma‐derived fibroblast‐like cells
Author(s) -
NOGITA T.,
TAKEHARA K.,
MORO A.,
OTSUKA F.,
ISHIBASHI Y.
Publication year - 1992
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1992.tb02528.x
Subject(s) - neurofibromatosis , fibroblast , neurofibroma , medicine , cancer research , platelet rich plasma , platelet , endocrinology , pathology , biology , cell culture , genetics
Summary The effect of platelet‐poor plasma from patients with von Recklinghausen's disease (neurofibromatosis, NF) on the cell growth of cultured neurofibroma‐derived fibroblast‐like cells (NF fibroblast‐like cells grown from plant cultures of cutaneous neurofibromas) was examined. Platelet‐poor plasma and sera from nine NF patients and nine control individuals were examined. When comparing platelet‐poor plasma from patients with NF with control individuals, the former stimulated the proliferation of fibroblast‐like cells derived from neurofibromas, not that of normal fibroblasts.