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Lymphocyte adenosine deaminase activity (L‐ADA) in leprosy, during and after treatment of reactions
Author(s) -
SEHGAL V.N.,
BHATTACHARYA S.N.,
SHAH Y.,
RAO Y.N.,
GUPTA C.K.
Publication year - 1992
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1992.tb02526.x
Subject(s) - adenosine deaminase , leprosy , medicine , adenosine , lymphocyte , immunology , adenosine deaminase deficiency , lymphocyte activation , immune system , t cell
Summary Twenty‐five patients with type 1 (lepra) and type 2 (E.N.L.) leprosy reactions were studied for lymphocyte adenosine deaminase activity (L‐ADA), during and after treatment of the reactions, using a standard technique, in order to establish its pattern and if possible, its value in assessing the course of reactions. The results were compared with those from 30 control subjects, comprising; 10 normal healthy adults, 10 patients with borderline tuberculoid (BT) leprosy, four patients with borderline lepromatous (BL) leprosy and six patients with lepromatous (LL) leprosy. The level of L‐ADA in the leprosy controls was higher than that of normal healthy subjects. The L‐ADA values in patients with different types of reactions were about 10‐fold higher than those obtained from leprosy controls, emphasizing a possible role in assessing reactions in leprosy. However, there was no significant variation in L‐ADA levels, cither between the various leprosy controls or reaction groups, before and after treatment.