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A primary cutaneous multi‐lobed B‐cell lymphoma
Author(s) -
VAILLANT L.,
MURET A.,
SORBIER C. MONEGIER,
MULLER C.,
LORETTE G.
Publication year - 1992
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1992.tb02165.x
Subject(s) - lymphoma , immunophenotyping , medicine , pathology , scalp , nodule (geology) , b cell , non hodgkin's lymphoma , biology , dermatology , antibody , antigen , immunology , paleontology
Summary Multi‐lobed non‐Hodgkin's lymphoma (NHL) has recently been recognized as a NHL variant. A patient presented with a scalp nodule which, upon skull X‐Ray, was seen to be associated with a bone detect. Immunophenotyping clearly demonstrated that this was a B‐cell proliferation. Histologically the B‐lympho‐cytes were closely related to centroblasts. There were no other extra cutaneous localizations. The present report emphasizes the importance of this clinico anatomical entity which shows prominent exta‐nodal involvement, large lymphoid cells with multi‐lobed nuclei and a good response to chemotherapy. Multi‐lobed NHL may be a T‐cell lymphoma, or a B‐cell lymphoma closely related to centroblastic NHL. Although multi‐lobed lymphomas have a predilection for cutaneous localizations, our case is the first primary cutaneous multi‐lobed B‐NTIL, proven by immunophcnotyping.