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Toxic epidermal necrolysis treated with cyclosporin
Author(s) -
HEWITT J.,
ORMEROD A.D.
Publication year - 1992
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1992.tb02163.x
Subject(s) - toxic epidermal necrolysis , medicine , dermatology , erythroderma
Summary Toxic epidermal necrolysis (TKN) is a severe life‐threatening disorder which has many features in common with graft‐versus‐host disease. However, imiriunosup‐pression with steroids gives disappointing results and is possibly detrimental. We treated two patients who had TEN with a combination of cyclosporin and steroids which resulted in an apparent halt to the evolution of the disease, and a further relapse was aborted using cyclosporin in one of these patients. We feel that the use of this drug in the early treatment of TEN where it is used as a specific therapy aimed at the primary immunopathological events and is used in conjunction with the supportive care patients require, needs to be further evaluated.