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Influence of amorolfine on the morphology of Candida albicans and Trichophyton mentagrophytes
Author(s) -
MÜLLER J.,
POLAKWYSS A.,
MELCHINGER W.
Publication year - 1992
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1992.tb00272.x
Subject(s) - ultrastructure , trichophyton , candida albicans , cytoplasm , microbiology and biotechnology , lysis , azole , cell wall , biology , chemistry , biochemistry , anatomy , antifungal
Summary Amorolfine applied in concentrations of 0·1‐100 μg/ml causes considerable damage to the ultrastructure of Candida albicans and Trichophyton mentagrophytes : electron‐lucent areas appear in the cytoplasm; extracytoplasmic membrane vesicles are formed and deposited in the cell wall; starved fungal cells, with normal ultrastructure, can be found; lysed, dead cells demonstrate the process of severe ultrastructural damage; T. mentagrophytes cell walls especially increase in thickness. The extent of the damage caused by amorolfine is comparable to that produced by azole antifungals.