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Pyoderma gangrenosum—response to topical nitrogen mustard
Author(s) -
TSELE E.,
YU R.C.H.,
CHU A.C.
Publication year - 1992
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1992.tb00254.x
Subject(s) - pyoderma gangrenosum , medicine , plasmapheresis , pyoderma , dermatology , nitrogen mustard , monoclonal gammopathy , surgery , neutrophilic dermatosis , monoclonal , chemotherapy , pathology , immunology , cyclophosphamide , monoclonal antibody , disease , antibody
Summary We report a 69‐year‐old Caucasian male patient with long‐standing pyoderma gangrenosum; the lesions preceded the appearance of an IgA monoclonal gammopathy by 2 years. A number of systemic treatments, including high dose steroids and immunosuppressive agents, were poorly tolerated and resulted in serious side‐effects. The skin and haematological conditions, however, were kept under control for 2 years with regular plasmapheresis. Pyoderma gangrenosum recurred as vascular access became exhausted but new lesions healed completely with topical application of 20% nitrogen mustard.