Premium
Role of sulphydryl‐containing agents in the management of venous (varicose) ulceration. A new approach
Author(s) -
SALIM A.S.
Publication year - 1992
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1992.tb00252.x
Subject(s) - varicose veins , medicine , dermatology , varicose ulcer , surgery
Summary This randomized double‐blind controlled study examined whether sulphydryl‐containing agents influence the healing of venous ulceration occurring for the first time on the medial side of the leg. Graduated compression bandaging, which exerted a mean ankle pressure of 40·6 ±0·4 mmHg, and a mean below‐knee pressure of 17·1 ±0·2 mmHg, healed 70% of ulcers within 12 weeks ( n = 46). The addition of the sulphydryl‐containing agents dl ‐cysteine ( n =46) or dl ‐methionine‐methyl sulphonium chloride ( n = 45) to the compression bandaging (daily application of the powder for 7 days, followed by once weekly applications until the end of the study 3 months later) significantly ( P < 0·01) stimulated healing of venous ulceration relative to control values when studied 4, 8 and 12 weeks after commencing treatment. After 3 months of treatment, both sulphydryl‐containing compounds healed 93% of the ulcers. The results show that sulphydryls stimulate healing of venous ulceration.