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Seborrhoea—an indicator for poor clinical response in acne patients treated with antibiotics
Author(s) -
LAYTON A.M.,
HUGHES B.R.,
MACDONALD HULL S.,
EADY E.A.,
CUNLIFFE W.J.
Publication year - 1992
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1992.tb00198.x
Subject(s) - acne , medicine , minocycline , erythromycin , benzoyl peroxide , isotretinoin , oxytetracycline , antibiotics , dermatology , antimicrobial , gastroenterology , microbiology and biotechnology , chemistry , polymer , organic chemistry , polymerization , biology
Summary The relationship between sebum excretion rate (SER) and clinical improvement was investigated in 255 acne patients treated For 6 months with either oral erythromycin (1 g/day), minocycline (100 mg/day), oxytetracycline (1 g/day) or cotrimoxazole (400 mg/day); topical therapy was 5% benzoyl peroxide. In all but the cotrimoxazole treated group, there was a significant correlation between a high SER and reduced clinical response. This was particularly evident in those patients with an SER of greater than 2–5 μg/cm 2 /min. These patients showed only 17% improvement compared with 100% improvement in those subjects with an SER of 1.0 μg/cm 2 /min or less. The presence of obvious seborrhoea in a patient who has failed to respond to an adequate 6–month course of antimicrobial therapy, should indicate the earlier rather than later use of isotretinoin for their acne.