Premium
Immunocytochemistry of eruptive haemangiomas (pyogenic granulomas)
Author(s) -
WEYERS W.,
ALLES J.U.
Publication year - 1991
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1991.tb01224.x
Subject(s) - immunocytochemistry , myofibroblast , pathology , monoclonal antibody , pericyte , endothelial stem cell , antibody , pyogenic granuloma , monoclonal , endothelium , medicine , biology , immunology , lesion , biochemistry , in vitro , endocrinology , fibrosis
Summary Eight eruptive haemangiomas (pyogenic granulomas) were stained immunocytochemically. Many of the cells reacted with markers for endothelial cells. The reactions with anti‐vWF antibody were weaker than those with UEA‐I‐lectin and with the monoclonal antibody BMA 120. These results probably reflect reduced capability for storage of vWF by proliferating endothelial cells. Many cells were negative for endothelial‐cell markers, and they reacted with a monoclonal antibody against muscle actin. These cells may be myofibroblasts and pericytes. The studies indicate that eruptive haemangiomas are composed of pericytes, myofibroblasts and endothelial cells.