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Treatment of pyoderma gangrenosum with cyclosporin A
Author(s) -
SORIA C.,
ALLEGUE F.,
MARTIN M.,
LEDO A.
Publication year - 1991
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1991.tb00409.x
Subject(s) - pyoderma gangrenosum , medicine , dermatology , dermatologic agents , antibiotics , microbiology and biotechnology , biology , disease
Summary Two patients with recalcitrant pyoderma gangrenosum were treated with oral cyclosporin A (5 mg/kg body‐weight/day). Healing of the lesions was achieved in Patient 1 within 1 month of starting treatment, but new areas of ulceration appeared when the dose was reduced to 3 mg/kg body‐weight/day. The ulcers showed marked improvement by 3 weeks after the start of treatment in Patient 2 and remained inactive at a maintenance dosage of 100 mg/day, but there was no change in the associated seronegative arthritis. A steroid‐sparing effect of CyA was evident in both patients. It is suggested that a lower dose of cyclosporin A than doses used previously in the treatment of pyoderma gangrenosum may be equally effective.