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Effect of UVB plus tar therapy on serum levels of interleukin‐2 receptors in patients with psoriasis
Author(s) -
BETTI R.,
ROSTI A.,
LODI A.,
BENCINI P.L.,
PAPARELLI S.,
GAZZOLA G.B.,
CORI P.,
MORONI G.A.,
CROSTI C.
Publication year - 1991
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1991.tb00402.x
Subject(s) - psoriasis , medicine , tar (computing) , atopic dermatitis , gastroenterology , receptor , interleukin , immunology , endocrinology , cytokine , computer science , programming language
Summary Baseline serum levels of interleukin‐2 receptor (IL2R) were measured in 65 patients with active psoriasis. IL2R levels in psoriatic patients were significantly higher than in healthy controls (582.4±289.23 u/ml vs. 369.64±111.10 u/ml; P < 0.05), but did not differ statistically from values found in an atopic dermatitis control group (619.88 ± 254.27 u/ml). Sex, age and severity of the disease do not affect levels of IL2R. The same IL2R levels were measured in 26 psoriatic patients receiving UVB plus tar therapy. This therapy, continued until clinical remission, lowered IL2R levels to values comparable to controls. This decrease may be due to an immunosuppressive effect of therapy.