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The phenotypic heterogenicity of bullous ichthyosis—a case report of three family members
Author(s) -
MCGRATH J.,
CERIO R.,
WILSONJONES E.
Publication year - 1991
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1991.tb00288.x
Subject(s) - ichthyosis , epidermolytic hyperkeratosis , hyperkeratosis , dermatology , dyskeratosis , medicine , congenital ichthyosis , ichthyosis vulgaris , biopsy , skin biopsy , pathology , atopic dermatitis , filaggrin
Summary We present a family with an inherited disorder of cornification. The clinical features are much less severe and developed much later in life than is usual in bullous ichthyosis. Skin biopsy demonstrated epidermolytic hyperkeratosis, a feature typical of bullous ichthyosis. The family is reported both to highlight the wide interfamilial variation that may occur in this condition and the value of histology in classifying this form of ichthyosis.