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Long‐term treatment of psoriasis with cyclosporin A—side‐effects, minimal effective dose and cyclosporin blood levels
Author(s) -
KORSTANJE M. J.,
STAAK W.J.B.M.
Publication year - 1991
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1991.tb00283.x
Subject(s) - psoriasis , medicine , ciclosporin , cyclosporins , term (time) , side effect (computer science) , chemotherapy , dermatology , surgery , transplantation , computer science , programming language , physics , quantum mechanics
Summary Fourteen patients with psoriasis received long‐term treatment with cyclosporin (CsA). Among patients there was great variability in the minimal effective CsA dose. In most patients long‐term treatment was limited due to dose reductions made necessary because of side‐effects. The therapeutic window for CsA seems small. CsA blood levels associated with side‐effects and with the minimal effective dose are in the same range and correlation between CsA blood levels and effectiveness in psoriasis is weak. Therefore, in CsA therapy for psoriasis, without concomitant medication which may influence CsA blood levels, the measurement of CsA blood levels is not necessarily helpful in optimizing therapy or preventing side‐effects.