Premium
Immunosuppressive therapy for pemphigus vulgaris complicated by malakoplakia of the bladder
Author(s) -
JORDAAN H.F.,
HEYNS C.F.,
ALLEN F.J.,
SCHNEIDER J.
Publication year - 1990
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1990.tb02140.x
Subject(s) - malakoplakia , pemphigus vulgaris , medicine , malacoplakia , pemphigus , dermatology , immunology , pathology
Summary Pemphigus vulgaris is an uncommon autoimmune disease which responds well to treatment with cortico‐steroids and azathioprine. Malakoplakia is a rare granulomatous disease associated with coliform infections and an altered cellular immune response. We report a 68‐year‐old female patient with pemphigus vulgaris who, after 2 years on maintenance prednisone and azathioprine immunotherapy, developed malakoplakia of the bladder associated with chronic E, coli urinary‐tract infection. The malakoplakia responded well to treatment with cotrimoxazole, bethanechol chloride and ascorbic acid, combined with tapering of the corticosteroid dosage. Our patient presents an uncommon but interesting complication of long term immunosuppressive therapy for pemphigus vulgaris.