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Adult xanthogranulomatosis associated with abnormal plasma apolipoprotein levels
Author(s) -
BERGMAN R.,
FRIEDMANBIRNBAUM R.,
AVIRAM M.,
KATZ I.,
KERNER H.,
BROOK J.G.
Publication year - 1990
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1990.tb02118.x
Subject(s) - isoelectric focusing , apolipoprotein b , medicine , lipoprotein , endocrinology , apolipoprotein e , plasma lipoprotein , cholesterol , high density lipoprotein , polyacrylamide gel electrophoresis , apolipoprotein c2 , immunoelectrophoresis , chemistry , gel electrophoresis , biochemistry , very low density lipoprotein , antibody , disease , immunology , enzyme
Summary A case of adult xanthogranulomatosis was investigated in depth for lipid abnormalities. The xanthogranulomatous lesion was shown to be composed primarily of cholesterol esters and triglycerides. Fasting plasma lipid levels and lipoprotein concentrations were within normal limits. Plasma lipoprotein electrophoresis and immunoelectrophoresis demonstrated normal high‐density lipoprotein (HDL) and low‐density lipoprotein mobilities. Polyacry‐lamide‐gel isoelcctric‐foeusing electrophoresis revealed increased levels of very‐low‐density apolipoprotein (apo) E, especially apo E‐III. In the HDL fraction, apo‐C‐III and apo‐E levels were both found to be slightly elevated. These findings might imply a causal relationship between the abnormal plasma apolipoprotein levels and the xamhogranulomatous disease.