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Cholesterol sulphate levels in the hair and nails of patients with recessive X‐linked ichthyosis
Author(s) -
SERIZAWA S.,
NAGAI T.,
ITO M.,
SATO Y.
Publication year - 1990
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1990.tb02010.x
Subject(s) - ichthyosis , corneocyte , scalp , stratum corneum , pathological , dermatology , cholesterol , congenital ichthyosis , nail (fastener) , medicine , pathology , materials science , metallurgy
Summary Cholesterol sulphate (CS) has been suggested as an intercellular glue fur corneocyte‐corneocyte cohesion from studies on patients with recessive X‐linked ichthyosis (RXLI). Pathological stratum corneum of RXLI patients was found to show a significant elevation of CS. In the present study hair and nails, unaffected keratinzed tissues in RXLI patients, were examined for CS levels. The results demonstrated significantly elevated CS levels in both tissues in RXLI patients ( P < 0.001). In particular the mean CS level in the hair of RXLI patients was five times greater than normal. The present study suggests that hair is a useful material for the diagnosis of RXLI.