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Paraneoplastic rhinophyma and the Leser–Trélat sign
Author(s) -
MAYOU S.C.,
BENN J.J.,
SONKSEN P.H.,
BLACK M.M.
Publication year - 1989
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1989.tb00946.x
Subject(s) - rhinophyma , medicine , rosacea , sign (mathematics) , dermatology , hemangiopericytoma , pathology , acne , mathematical analysis , mathematics
Summary A case of the Leser‐Trelat sign associated with an underlying malignant haemangiopericytoma is described. In addition, the patient had profound hypoglycaemia and a rhinophyma‐like nasal swelling which rapidly resolved post‐operatively. The tumour appeared to be secreting a factor(s) which cross‐reacted with both insulin receptors to induce hypoglycaemia and epidermal growth factor receptors inducing a profusion of eruptive seborrhoeic warts. It also had marked sebotrophic activity. The association of the Leser‐Trélat sign with malignant haemangiopericytoma has not previously been described.