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Two cases of nodular cutaneous amyloid with positive organ‐specific antibodies, treated by shave excision
Author(s) -
GRATTAN C.E.H.,
BURTON J.L.,
DAHL M.G.C.
Publication year - 1988
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1988.tb01967.x
Subject(s) - medicine , autoantibody , pathology , amyloid (mycology) , thyroid , amyloidosis , antibody , dermatology , immunology
Summary Two cases with nodular cutaneous amyloid on the face were treated by shave excision with excellent cosmetic results. Both showed positive thyroid microsomal and gastric parietal cell autoantibodies but no evidence of systemic amyloidosis. The presence of autoantibodies raises the possibility that primary cutaneous nodular amyloid may be associated with autoimmune disorders. Primary nodular cutaneous amyloid is an uncommon disorder. A recent view of the literature has identified 47 reported cases to date. 1 The nodules are usually confined to the skin so the prognosis tends to be good, although systemic amyloidosis 2 and associated monoclonal gammopathy 3 have been recorded. Of 12 cases in the Japanese literature, four have been associated with Sjogren's syndrome, 4 which itself is associated with the presence of specific and non‐organ specific autoantibodies.