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Abnormalities in clinically normal skin–a possible explanation of the‘angry back syndrome’
Author(s) -
HAMAMI I.,
MARKS R.
Publication year - 1988
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1988.tb00715.x
Subject(s) - transepidermal water loss , medicine , dermatology , stimulation , skin reaction , stripping (fiber) , blood flow , pathology , materials science , stratum corneum , composite material
Summary In this study cutaneous blood flow, skin temperature, transepidermal water loss and the histological picture have been investigated at locations near to sites subjected to inflammatory stimuli. The inflammatory reactions were produced experimentally by irradiation with UVR, by ‘stripping’ with adhesive tape, by the application of 10% sodium lauryl sulphate and by application of 5% nickel sulphate to nickel sulphate‐sensitive subjects. Significant increases in cutaneous blood flow occurred subsequent to UVR irradiation and tape stripping with stimuli insufficient to cause observable clinical sequelae. Increase in transepidermal water loss also occurred after ‘subthreshold’ UVR stimulation. Some of the observations made suggested that the reactions became less intense the further away from the site stimulated the observations were made. In addition, histological abnormalities were found in clinically normal skin at the site of a cutaneous inflammatory response. Both previous observations and the present data suggest that inflammatory responses in the skin are not confined to the apparently reacting site but that skin also responds elsewhere at distant and apparently clinically normal areas.